1 research outputs found
Prosomeric organization of the hypothalamus in an elasmobranch, the catshark Scyliorhinus canicula
The hypothalamus has been a central topic in neuroanatomy because of its important
physiological functions, but its mature organization remains elusive. Deciphering its
embryonic and adult organization is crucial in an evolutionary approach of the
organization of the vertebrate forebrain. Here we studied the molecular organization
of the hypothalamus and neighboring telencephalic domains in a cartilaginous
fish, the catshark, Scyliorhinus canicula, focusing on ScFoxg1a, ScShh, ScNkx2.1,
ScDlx2/5, ScOtp, and ScTbr1 expression profiles and on the identification αacetylated-tubulin-immunoreactive (ir), TH-ir, 5-HT-ir, and GFAP-ir structures by means
of immunohistochemistry. Analysis of the results within the updated prosomeric model
framework support the existence of alar and basal histogenetic compartments in the
hypothalamus similar to those described in the mouse, suggesting the ancestrality
of these subdivisions in jawed vertebrates. These data provide new insights into
hypothalamic organization in cartilaginous fishes and highlight the generality of key
features of the prosomeric model in jawed vertebrates.This work was supported by grants from the Spanish Dirección General de Investigación-FEDER (BFU2010- 15816), the Xunta de Galicia (10PXIB200051PR, CN 2012/237), European Community-Research Infrastructure Action under the FP7 “Capacities” Specific Programme (ASSEMBLE 227799), the Région Centre, Région Bretagne (EVOVERT grant number 049755; PEPTISAN project), National Research Agency (grant ANR-09-BLAN-026201), CNRS, Université d’Orléans and Université Pierre et Marie Curie. GNSD would like to thank Spanish SEPE for its funding supportS